Clomiphene Citrate Effectively Increases Testosterone in Obese, Young, Hypogonadal Men

Clomiphene Citrate Effectively Increases Testosterone in Obese, Young, Hypogonadal Men.

BACKGROUND Obesity has been associated with low testosterone (T) in adult males and in pubertal boys. Therapy for hypogonadism with exogenous T may lead to testicular atrophy and later infertility. Only a few studies have demonstrated that the Selective Estrogen Receptor Modulator (SERM) clomiphene citrate (CC), an estrogen receptor antagonist, increases T in obese hypogonadal men while prevent...

Rosiglitazone increases testosterone in hypogonadal type 2 diabetic men.

Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.

OBJECTIVES To determine the effects of daily oral doses of enclomiphene citrate compared with topical testosterone gel treatment on serum total testosterone (TT), luteinising hormone (LH), follicle-stimulating hormone (FSH), and sperm counts in men with secondary hypogonadism. PATIENTS AND METHODS Two parallel randomised, double-blind, double-dummy, placebo-controlled, multicentre, phase III ...

Testosterone versus clomiphene citrate in managing symptoms of hypogonadism in men

INTRODUCTION Both clomiphene citrate (CC) and testosterone supplementation therapy (TST) are effective treatments for men with hypogonadism. We sought to compare changes in symptoms and treatment efficacy in hypogonadal men before and after receiving CC and TST. PATIENTS AND METHODS 52 men who received TST and 23 men who received CC for symptomatic hypogonadism were prospectively followed for...

Compounded percutaneous testosterone gel: use and effects in hypogonadal men.

BACKGROUND Current methods of testosterone replacement therapy are limited to fixed-dosage patches and depot injections. Neither of these methods provides ideal therapy because of the inflexibility of dosing and other nuisance problems associated with the patches and nonphysiologic hormone levels when depot injections are used. Testosterone gels offer the potential for convenience and ease of a...